What Causes CMT?

How do you get CMT disease?

Charcot-Marie-Tooth disease is an inherited, genetic condition.

It occurs when there are mutations in the genes that affect the nerves in your feet, legs, hands and arms.

Sometimes, these mutations damage the nerves.

Other mutations damage the protective coating that surrounds the nerve (myelin sheath)..

Can CMT be passed from father to daughter?

This change is called a mutation. Some genetic mutations are hereditary, meaning they can be passed down from a parent to their child. CMT is caused by hereditary genetic mutations. But just because someone has CMT doesn’t mean they got it from one of their parents.

Can CMT affect your eyes?

CMT Type 6 involves development of optic atrophy with loss of vision or blindness, muscle atrophy and weakness, loss of sensation, and balance and gait difficulties. Depending on the genetic cause of the CMT Type 6, there may be other symptoms including delayed learning.

Is CMT always inherited?

CMT type 4 involves many different genes, but its main distinguishing feature is that it is always inherited in an autosomal recessive manner: a single copy of the normally functioning gene can prevent disease symptoms from manifesting.

CMT, Multiple Sclerosis (MS) and Muscular Dystrophy (MD)are three completely separate and distinct diseases.

Is CMT painful?

Paradoxically, despite sensory loss, some people with CMT experience pain — a combination of painful muscle cramps and neuropathic pain. This pain is not caused by an external trigger but by defective signals in sensory axons. Both types of pain usually can be alleviated with medication.

Can CMT skip a generation?

CMT does not skip generations genetically. For people with autosomal dominant and X-linked conditions, a person will either have the condition or not. If a parent has CMT that has been genetically confirmed, a child can be tested when that child is at least 18 years of age and with appropriate genetic counseling.

Who is most likely to get Charcot Marie Tooth disease?

Symptoms of CMT hereditary neuropathy usually begin gradually sometime in adolescence, early adulthood or middle age. The condition affects an equal number of males and females. CMT hereditary neuropathy is the most common inherited neurological disorder affecting more than 250,000 Americans.

Is CMT considered a disability?

Medically Qualifying Under A Disability Listing: CMT is a form of peripheral neuropathy, meaning it affects the nerves and muscles in the arms, legs, hands, and feet. The Social Security Administration (SSA) has a standard disability listing for this type of neurological disorder.

Does CMT make tired?

Fatigue is a common symptom in CMT. A study, published in the Journal of Neurology in 2010 and based on questionnaire given patients and an age- and sex-matched control group, reported that fatigue levels were significantly higher in people with CMT. Fatigue in CMT can be due to a number of reasons.

How is CMT passed down?

CMTX is inherited in an X-linked dominant pattern . A condition is considered X-linked if the mutated gene that causes the disorder is located on the X chromosome. The inheritance is dominant if one copy of the altered gene is sufficient to cause the condition.

Does CMT affect speech?

Some people also develop additional problems, such as: uncontrollable shaking (tremor) abnormal curvature of the spine (scoliosis) problems speaking, breathing or swallowing (dysphagia) – these symptoms are rare in CMT.

Does CMT affect memory?

The most common cause of CMT is the duplication of a region on the short arm of chromosome 17, which includes the gene PMP22. We report a thirty-seven-year-old man with CMT disease having sleep, memory and attention disorders characterized by brief retrograde amnesia at early age.

At what age does CMT present?

The symptoms of CMT usually start to appear between the ages of 5 and 15, although they sometimes do not develop until well into middle age or later. CMT is a progressive condition.

Does CMT affect your brain?

Unlike other neurological disorders, CMT usually isn’t life-threatening, and it almost never affects the brain. It causes damage to the peripheral nerves — tracts of nerve cell fibers that connect the brain and spinal cord to muscles and sensory organs.